Custom Peptides
Cayman Chemical KBP066trIfluoroACTAte sal 10mg
A dual amylin and calcitonin receptor agonist; reduces body weight and food intake in rats fed a high-fat diet 50 UG/kg; prevents increases in fasting blood glucose levels in fa/fa Zucker diabetic fatty rats
Cayman Chemical C10 CeramIded18 110 0 10mg
A bioactive sphingolipid; inhibits growth of wild-type and MDR1 gene-transfected MDA435/LCC6 human breast cancer cells (IC50s = 44.1 and 46 μM, respectively); inhibits the growth of J774 murine macrophages in a dose-dependent manner
Cayman Chemical zngbr offIcnle 8Gngerol 10mg
A natural chemical that activates TRPV1 (EC50 = 5.0 µM), inhibits COX-2, and inhibits the growth of H. pylori in vitro; also augments wound healing, suppresses IL-2-induced proliferation of T lymphocytes, and potentiates β-agonist-induced relaxation of airway smooth muscle
Cayman Chemical 1mthyl1 4dIhydronIcotInam 10mg
A nicotinamide derivative; inhibits β-elimination activity of hSR (IC50 = 177 μM)
Cayman Chemical EnterostatInhumnmouser 10mg
A pentapeptide involved in the regulation of food intake; binds to mitochondrial complex V, also known as F1F0 ATP synthase in a cell-free assay; inhibits ATP production and increases thermogenesis in INS-1 insulinoma cells; reduces body weight in rats fed a high-fat diet; reduces food intake in wild-type, but not Mc4r-/-, mice at 1 nmol, i.c.v.; enhances memory consolidation in mice in a passive avoidance test at 300 mg/kg
Cayman Chemical EG 00229trIfluoROCTAte sa 10mg
An NRP-1 antagonist; inhibits the binding of VEGF-A to porcine aortic endothelial cells expressing NRP-1 but not VEGFR2 (IC50 = 8 µM); reduces VEGF-A-induced migration of HUVECs and enhances the cytotoxicity of paclitaxel or 5-fluorouracil in A549 lung cancer cells; reduces SARS-CoV-2 infectivity in Caco-2 cells at 100 µM
Cayman Chemical BrombuterolhydrochlorIde 10mg
A β2-AR agonist; has been used as an illicit feed additive to increase the muscle-to-fat ratio of livestock
Cayman Chemical Efondpn 10mg
An L- and T-type calcium channel inhibitor; inhibits hamster Cav1.2a and human Cav3.2 (IC50s = 1.8 and 350 nM, respectively); inhibits L- and T-type calcium channels and fetal bovine serum-induced hypertrophy in isolated mouse cardiomyocytes; increases survival in a mouse model of acute myocardial infarction induced by ligation of the left coronary artery at 200 mg/kg; inhibits SARS-CoV-2 Mpro (IC50 = 38.5 µM)
Cayman Chemical Cornus ofcnals Verbenaln 10mg
An iridoid glucoside; inhibits the activities of COX-1 and COX-2 by 37 and 48%, respectively, at 258 µM; inhibits proliferation of AGS gastric, SF-268 CNS, HCT116 colon, NCI H460 lung, and MCF-7 breast cancer cells at 129 µM; reduces carrageen-induced paw edema and TPA-induced EAr dema in mice; reduces increases in MDA levels and ROS production in isolated brain mitochondria isolated from, as well as decreases infarct volume and neurological deficits in, a rat model of MCAO-induced ischemia-reperfusion injury
Cayman Chemical RS 17053hydrochlorIde 10mg
An α1A-AR antagonist; selectively binds to the α1A-AR (Ki = 2.5 nM) over α1B-and α1D-ARs (Kis = 50 and 79 nM, respectively); inhibits norepinephrine-induced contractions in isolated rat kidney and mesenteric arteries (pA2s = 9.8 and 9.9, respectively) and, to a lesser extent, in isolated rat aortic rings and human lower urinary tract tissue (pA2s = 7.7 and 7.3, respectively); inhibits phenylephrine-induced increases in MAP in normotensive and spontaneously hypertensive rats (ED50s = 528 and 533 UG/kg, respectively)
Cayman Chemical Valna ofcnals L Valtat 10mg
A valepotriate with diverse biological activities; inhibits nuclear export of influenza vRNP in HeLa cells at 3.6 µM; inhibits influenza virus infection in MDCK cells (IC50 = 0.19 µM); cytotoxic to GLC-4 and COLO 320 cells (IC50s = 1.4 and 3 µM, respectively); increases the number of entries into, and percentage of time spent in, the open arms of the elevated plus maze, indicating anxiolytic-like activity, and decreases serum corticosterone levels in rats at 10 mg/kg
Cayman Chemical BenocyclIdIn-d10 10mg
An internal standard for the quantification of benocyclidine by GC- or LC-MS
Cayman Chemical SynthetIc TrIcIn 10mg
A flavone with diverse biological activities; scavenges ABTS radicals in a cell-free assay (IC50 = 0.312 mg/ml); reduces virus titer and expression of IE1 and UL54 in HCMV-infected HEL cells from 0.1-10 µM; inhibits IgE-induced degranulation of RBL-2H3 cells (IC50 = 4.83 µM); reduces tumor growth and the number of lung metastases in a CT26 murine colon carcinoma model at 37.5 mg/kg per day
Cayman Chemical LRRKtIDtrIfluoROCTAte sa 10mg
A peptide substrate for LRRK2; has been used to identify inhibitors of LRRK2
Cayman Chemical TrIcosnoyl EthnolamIde 10mg
A member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids